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Pyrvinium pamoate
CAS No. 3546-41-6
Pyrvinium pamoate ( Pyrvinium embonate )
产品货号. M14210 CAS No. 3546-41-6
一种有效的蛲虫驱虫剂，是 Wnt 信号传导的有效抑制剂，EC50 为 10 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥251 | 有现货 |
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| 10MG | ￥389 | 有现货 |
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| 25MG | ￥518 | 有现货 |
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| 50MG | ￥656 | 有现货 |
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| 100MG | ￥972 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Pyrvinium pamoate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种有效的蛲虫驱虫剂，是 Wnt 信号传导的有效抑制剂，EC50 为 10 nM。
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产品描述An anthelmintic effective agent for pinworms that shows to be a potent inhibitor of Wnt signaling with EC50 of 10 nM; binds to all CK1 family members in vitro at low nanomolar concentrations and selectively potentiates CK1α kinase activity; inhibits Wnt signaling downstream of β-catenin, and promotes Pygopus degradation; also is a potent inhibitor of HH signaling by reducing the stability of the Gli family of transcription factors.
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体外实验——
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体内实验——
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同义词Pyrvinium embonate
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通路Metabolic Enzyme/Protease
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靶点Casein Kinase
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受体Casein Kinase
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研究领域——
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适应症——
化学信息
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CAS Number3546-41-6
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分子量575.7
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分子式C26H28N3 . 1/2 C23H14O6
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 24 mg/mL
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SMILESCN(C)C1=CC2=C([N+](C)=C(/C=C/C3=C(C)N(C4=CC=CC=C4)C(C)=C3)C=C2)C=C1.CN(C)C5=CC6=C([N+](C)=C(/C=C/C7=C(C)N(C8=CC=CC=C8)C(C)=C7)C=C6)C=C5.[O-]C(C9=CC%10=C(C=CC=C%10)C(CC%11=C(O)C(C([O-])=O)=CC%12=C%11C=CC=C%12)=C9O)=O
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化学全称Quinolinium, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-, 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (2:1)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Thorne CA, et al. Nat Chem Biol. 2010 Nov;6(11):829-36.
2. Li B, et al. Cancer Res. 2014 Sep 1;74(17):4811-21.
3. Li B, et al. Sci Signal. 2017 Jun 27;10(485). pii: eaak9916.
